The Agency (Organismo para la Proscripción de las Armas Nucleares en la América Latina y el Caribe) was established following the Cuban missile crisis to guarantee implementation of the world’s first Nuclear-Weapon-Free-Zone (NWFZ) in the region. Created by the Treaty of Tlatelolco (1967), OPANAL is an inter-governmental agency responsible for ensuring that the requirements of the Treaty are enforced. OPANAL has played a major role in establishing other NWFZs throughout the world.