In today’s rapidly evolving landscape of data science and artificial intelligence, setting up a robust and versatile programming environment is foundational to success. R was initially developed for statistical analysis and has expanded into a powerful tool for machine learning and, more recently, Generative AI. This chapter guides you through configuring your R environment specifically for Generative AI applications, covering essential tools, packages, and configurations that will enhance your workflow, improve reproducibility, and enable the development of cutting-edge models. By the end of this chapter, you will have a well-organized R setup that’s capable of tackling the complexities of Generative AI, empowering you to bring your ideas to life with confidence and efficiency.