Cell Wall-Anchored Surface Proteins of Staphylococcus aureus
摘要
Staphylococcus aureus expresses a plethora of proteins that are covalently anchored to cell wall peptidoglycan. They are classified on the basis of structural and functional properties. Several proteins are multifunctional. They promote adhesion to host cells and tissue, invasion of non-phagocytic host cells, evasion of innate and adaptive immune responses, biofilm formation and iron acquisition. Their roles in host colonization and pathogenesis of infectious diseases have been demonstrated in animal models.