Clinical Management of CIN Including Recent Therapeutic Strategies

CIN is clearly caused by HPV infection, but the pathogenesis is thought to differ between CIN1 and CIN2/3. A recent morphological definition classifies CIN1 (LSIL) as a lesion indicating HPV infection and CIN2/3 (HSIL) as a neoplastic lesion. No treatment is needed for CIN1 because it has no symptoms and mostly regresses spontaneously. However, CIN2/3 is a precancerous lesion of cervical cancer and is therefore considered to be a candidate for treatment intervention to reduce the risk of cervical cancer. The only treatment available for CIN2/3 at present is surgical treatment. However, it is not clear why a therapeutic drug remains undeveloped for CIN2/3. In this review, we discuss the current progress in drug discovery for CIN2/3.