Preoperative Treatment of Duodenal Gastrointestinal Stromal Tumors

Duodenal GIST account for 12–18% of small intestinal GIST and 1–3% of all GIST. Surgical treatment is still the primary treatment for localized GIST. Because of the special anatomical location of duodenal GIST, immediately adjacent to the pancreatic head and biliary tract, complex surgical methods are required, and surgeons must consider surgical methods according to specific anatomical sites, tumor size, and other factors. The preoperative treatment of GIST has an important role, as some unresectable tumors shrink after targeted therapy, reducing the possibility of multi- organ resection, such as pancreaticoduodenectomy, increasing the resection rate, and reducing surgical trauma.