Management of Targeted Drug Adverse Reaction

Imatinib is an effective treatment for GISTs. The vast majority of patients with GISTs benefit from imatinib treatment, but there will be side effects in the process of taking medicine. A small number of patients cannot tolerate imatinib due to serious side effects, so they require treatment with second-line drugs. Targeted drugs can cause interstitial lung disease, mainly by affecting the EGFR signal pathway, and the mechanism is not completely clear. Similar findings have been found in the pulmonary toxicity of other chemotherapeutic drugs, such as gemcitabine and paclitaxel.