Gastrointestinal Stromal Tumors with Kidney Cancer

GIST are a common GI tumor originating from mesenchymal tissue. The incidence of synchronous tumors involving GIST is not as low as it appears to be. According to long term follow-up data from the MD Anderson cancer center, approximately 20% of patients with GIST also have another synchronous tumor. It remains rare that non-familial or general GIST are accompanied by another malignant tumor synchronously. Synchronous renal cancer with GIST is also uncommon. Recent studies have shown a connection between the pathogenesis and treatment for these two malignancies as described in this chapter.