Multiple Gastrointestinal Stromal Tumors

GIST are generally found as a single tumor, and multiple GIST are usually seen in familial GIST or in some syndromes, such as NF1 and Carney syndrome. Primary multiple sporadic GIST (multiple sporadic GIST) is relatively rare, and is sometimes difficult to detect with preoperative imaging examination or endoscopy, and there may be missed diagnosis or misdiagnosis. Therefore, attention should be paid to the possibility of multiple GIST in clinic. In addition, the pathogenesis and pathological risk classification schemes for multiple GIST are still inconclusive, and treatment is controversial. Here, we will share our experience in the diagnosis and treatment of two patients with primary multiple sporadic GIST from the perspectives of clinical manifestations, relevant examinations, surgical treatment, and pathological diagnosis.