Mitotic Extremely High Gastrointestinal Stromal Tumors

The grading criteria of a GIST directly affect the selection of treatment strategies, and the current GIST grading criteria were mainly developed based on parameters such as tumor size, number of mitotic count, tumor location, and tumor rupture, but these criteria cannot accurately predict the probability of GIST recurrence. At present, the academic community generally recognizes that mitotic count have a high weight, and the existing NIH risk classification cannot provide an individualized prediction of GIST recurrence and prognosis, especially regarding the prognosis of patients with high mitotic count. From this, it can be seen that it is insufficient to grade the risk of GIST by relying solely on the conventional pathological features of the tumor. The ultimate goal of ideal assessment criteria is to reveal the biological nature of GIST and to guide clinically reasonable treatment. At present, many evaluation criteria cannot reasonably predict the risk of GIST recurrence, thus making clinical treatment difficult, especially for patients with a certain risk of recurrence.