Positive-Unlabeled Learning with Field of View Consistency for Histology Image Segmentation

Histology image annotation is costly and time-consuming. Utilizing Positive and Unlabeled (PU) data for model training offers a more resource-efficient alternative. However, previous methods for PU learning suffer from the noise arising from label assignment to unlabeled data. We observe that predictions on noisy data lack consistency under data augmentation. In this paper, we present Field of View (FoV) consistency regularization for PU segmentation in histology images, which effectively reduces the noise influence by promoting consistent predictions across varying FoVs. Using only 20% of positive labels on the Glas Dataset, our approach outperforms previous methods, achieving a Dice score of 90.69%-almost reaching the fully supervised result of 93.30%. Source code is available at: https://github.com/lzaya/PU_with_FoV .