Secondary Hemochromatosis

Hemochromatosis is a rare disorder characterized by deposition of excess of iron that causes multiple organ dysfunction. Secondary hemochromatosis occurs because of chronic blood transfusions in conditions such as hemoglobinopathies, conditions with ineffective erythropoiesis, or chronic inflammatory diseases. For effective management, early diagnosis is important since it results in organ damage. In this chapter, a clinical case scenario is presented followed by a step-by-step evidence-based approach to utilize specialized and advanced tests to unravel final diagnosis of hemochromatosis. A comprehensive description of pathophysiology of disease, initial test of choice for diagnosing iron overload and tests recommended for follow-up in such patients are discussed in question–answer format. Salient points are summarized for quick revision. To gain expertise in this topic and enhance your diagnostic skills for effective planning of management, read this chapter on secondary hemochromatosis.