Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury?

Peripheral nerve injury often induces chronic neuropathic pain. Peripheral nerve consisted of sensory fibers and motor fibers; it is questioned injury to which type of fibers is responsible for generation of neuropathic pain? Because neuropathic pain is a sensory disorder, it is generally believed that the disease should be induced by injury to sensory fibers. In recent years, however, emergent evidence has shown that motor fiber injury but not sensory fiber injury is necessary and sufficient for induction of neuropathic pain. Motor fiber injury leads to neuropathic pain by upregulating pro-inflammatory cytokines and brain-derived neurotrophic factor in the pain pathway.