Bacteriophage Therapy to Combat ESKAPE Pathogens

Anti-microbial resistant ESKAPE pathogens are global threat to human due to their pathogenecity. These pathogens cause a substantial percentage of nosocomial infections in modern hospitals. However, these pathogens show antibiotics resistant property and thus it is a challenging task to eliminate them. Alternative therapy like bacteriophage therapy has drawn attention to treat these pathogens. Bacteriophages are natural killer of bacteria, and they destroy the host cell completely. They are abundant in nature and also effective against drug-resistant pathogens. It had been observed by animal model that either treatment with them or with their enzymes or synergistically with other therapeutic agents shows activity against pathogens. In this chapter, we will review the process of bacteriophage therapy and how they have been used to treat against ESKAPE pathogens.