Pseudomonas aeruginosa Virulence Factors and Biofilm Components: Synthesis, Structure, Function and Inhibitors

Pseudomonas aeruginosa is a versatile opportunistic bacterium reasons for hospital-acquired infections specifically to the patients suffering from cystic fibrosis, burns, wounds and also immunocompromised individuals. Diverse resistance mechanisms possessed by the bacterium make them to overcome the effect of various antimicrobial agents. P. aeruginosa possess a plenty of virulence determinants, specifically biofilm, and triggers resistance, which is controlled by cellular communication pathway called quorum sensing (QS). A deep understanding about the pathogenic determinants such as virulence factor and biofilm, and also the interaction with the host, makes the development of therapeutic approaches easier. This chapter gives an insight into the synthesis, structure, function and inhibitors of virulence phenotypes of Pseudomonas aeruginosa.