Acinetobacter baumannii Virulence Factors and Biofilm Components: Synthesis, Structure, Function, and Inhibitors

Acinetobacter baumannii (A. baumannii) is a Gram-negative opportunistic human pathogen, and the drastic dissemination of multidrug resistance in A. baumannii is presently posing a serious concern in healthcare settings. This bacterium has the ability to multiply and produce various virulence factors and biofilm formation on the surface of host cells. Due to the production of virulence factors and biofilm formation, the bacteria’s ability contributes to chronic or persistent infections and resistance to various antibiotic substance. In this chapter, we mainly focus on the mechanisms of quorum sensing-controlled virulence factors, drug resistance, and biofilm formation of A. baumannii and a brief account of quorum sensing (QS) inhibitors and anti-biofilm compounds as an alternative therapeutic treatment for multidrug-resistant A. baumannii.