Computational Studies of Phytochemicals from Allium Sativum with H7N9 Subtype in Avian Influenza

Allium sativum or garlic is a medicinal plant that is reported for its applications in many biological activities, such as its antiviral, anti-diabetic, anti-inflammatory properties etc. In this paper, the focus has been the identification of potential phytochemicals that can be extracted from Allium sativum that can act as a candidate which possesses the capability to inhibit the H7N9 Avian Influenza, a type of highly pathogenic and zoonotic strain that presents a significant threat to the public healthcare systems. Using computational tools and methods, screening of the 145 phytochemicals from Allium sativum was done against a major H7N9 protein Neuraminidase (NA). The molecular interaction study with the help of computational molecular docking indicated that many compounds have stable interaction with high binding affinity towards Neuraminidase (NA). These results suggest that phytochemicals from Allium sativum can be promising candidates for development of therapeutic agents against H7N9 virus for management of Avian Influenza.