Biosensing Technologies for Detection of Extracellular Vesicles
摘要
Extracellular vesicles (EVs) are novel biomarkers evaluated during liquid biopsy and are involved in many physiological functions in cells as well as various pathological processes in diseases. There is an urgent need for a specific, sensitive, and rapid detection platform to facilitate clinical diagnosis. Researchers have recently developed new biosensing technologies for the detection of EVs owing to their unique advantages. In this chapter, we review recent developments and technical breakthroughs in biosensor-based EV detection, including electrochemical, fluorescent, chemiluminescent, surface plasmon resonance, Raman spectroscopy, and other biosensors, in the field of cancer and other diseases. The working strategies, analytical performance, advantages, shortcomings, and future perspectives of these biosensors are summarized.