Wearable Artificial Pancreas Device Technology

This chapter covers the development of closed-loop insulin delivery systems known as artificial pancreas systems (APSs). These systems can be either electronics-based or electronics-free, and there is a continuous drive to make them both wearable and user-friendly. First, we outline the development and validation status of electronics-based APSs. Then, we summarize the growing research effort to develop electronics-free, chemically-controlled APSs, with particular emphasis on ongoing efforts to make them wearable. We also discuss current challenges, possible solutions, and future perspectives based on promising results from a recent clinical trial.