Myasthenia Gravis and Neurocritical Care

Acquired myasthenia gravis (MG) is an autoimmune disorder directed against the neuromuscular junction (NMJ). The diagnosis of MG is based on the clinical history and examination demonstrating characteristic pattern of fluctuating, fatigable weakness in ocular, bulbar, respiratory, or limb muscles [1]. The presence of neuromuscular junction disorder needs to be confirmed by immunological and electrophysiological testing. MG is a rare disorder, but incidence is estimated to be 5 and 30 lacs cases per 1 million-person year [2, 3]. A bimodal peak is described with one peak around 30 year and another peak among 50 years [4, 5]. One should understand that as all patients might not have the classic clinical presentation, list of differential diagnosis for motor weakness and ocular weakness should be generated.