Sepsis in Neurocritical Care

Sepsis is one of the most actual problems of medicine and healthcare systems. In Russia, sepsis is diagnosed in almost one million people each year [1]. A comparable level of sepsis development is typical for Europe and the United States [2, 3]. An unfavorable epidemiological feature of sepsis is an increase in its frequency and severity during the last decades [4, 5]. One of the greatest epidemiological problems is the absence of exact number of cases with sepsis worldwide due to diagnostic difficulties and issues, related to the interpretation of sepsis criteria. A rough assessment of the occurrence of sepsis worldwide is 31.5 million cases annually, and 5.3 million deaths are associated with sepsis [4, 6, 7]. Obviously, sepsis is a typical issue of intensive care, since multiple organ dysfunction syndrome is the essence of sepsis.