Evolutionary selection for survival and fitness favors bidirectional interactions between dynamic and malleable gut microbes and their hosts. By doing so, dynamic host inter-organ and gut microbiota-organ communications exchange information in an age and sex-dependent manner. An individual’s lifespan is determined by organ decline, “biological aging,” which accelerates if microbiota composition becomes impaired, due to excessive intake of unhealthy diet, and/or when the host practices an excessively unhealthy lifestyle. In this chapter, we pay attention to new trends in host microbiome research, especially on the relevance and possible link to changes in the oral microbiome as a potential tipping point for further fueling and accelerating biological aging and on how regional dietary interventions may be used to attenuate host chronic inflammation in geographically defined areas, and the possibilities of public health policies revolving around developing next-generation dietary intervention programs, specific food products, and public health nutrition programs as a means to slow down biological aging.