PCOS Investigations and Clinical Implications

Stein and Leventhal 1935 provided the first description of PCOS noting varying degrees of enlarged ovaries, obesity, hirsutism, and chronic anovulation. It is generally accepted that PCOS is not a specific endocrine disease but a syndrome represented by a collection of signs and symptoms [1–8]. No one sign or symptom is diagnostic, thus establishing diagnostic criteria is both challenging and controversial, knowing and understanding health implications are far more important than establishing the diagnosis of PCOS.