Solid Xenoorgan Xenotransplantation

Besides the immunological damages, the xenotransplantation also induces several blood and vascular damages through fatal hemorrhagic coagulation, phagocytotic cell death, and activation of platelets as thrombocytopenic consequence. Several biochemical events such as inflammatory response and thrombotic failure occur at xenotransplantation of solid organs. Therefore, to preventively suppress such events, several regulating factors including anti-coagulant factor, anti-inflammatory factor, and cytoprotection factor-expressing pig transgenic strains are strategically considered. From the mice experiments, human EPCR-expressing transgenic mice protect themselves from reperfusion injury of warm renal ischemia. Heart organs of these mice showed the prolonged survival time when the organs were heterotrophic-transplanted in C6-deleted rats and showed less hemorrhage and edema levels [1].