Application of Metabolomics for the Discovery of Potent Antimicrobials from Plants

One of the major goals of studying metabolome and metabolism has long been to find biomarkers for disease diagnosis and prognosis. The significance of metabolomics has been transformed from a straightforward biomarker identification tool to a technology for the detection of active biological process drivers, nevertheless. It is now understood that the metabolome modifies other “omics” levels, including as the genome, epigenome, transcriptome, and proteome, in order to influence cellular function. In this chapter, we highlight the strategies to use metabolomics to uncover the active function of metabolites in physiology and disease by understanding how the metabolome is useful in screening and to identify the active molecules from natural sources such as plants and their mode of action. The idea of using activity screens to find biologically active compounds using metabolomics, or what we call activity metabolomics, is already having a significant impact on biology.