Effect of Arterial Flow on Heat Transfer During Magnetic Hyperthermia Application

This paper investigates the effects of location arterial flow on heat transfer during hyperthermia applications. A three-dimensional tumor model consisting of a blood vessel (artery) is modeled and simulated for magnetic hyperthermia physics. The location of the blood vessel (artery) with respect to the tumor is altered in the tumor models and it passes through different positions from the tumor center. The size (diameter) of the artery is 4 mm, and the tumor size is 10 mm. The different artery positions x = 3, 6, 9, and 12 mm from the tumor center are considered in the physical models. Results show that the position of the artery plays a crucial role in heat dissipation from the tumor volume during magnetic hyperthermia. The therapeutic temperature in the tumor tissue decreases when an artery is closer to the tumor center. This is due to the higher heat transfer effect induced by arterial blood flow. However, when the artery is located at the periphery or away from the tumor, higher temperature is induced in the tumor volume during magnetic hyperthermia in comparison to the cases when the artery is located deep inside the tumor volume.