Clinical Trial with Synbiotics in Various Disease State

Simultaneous use of prebiotics and probiotics for human health benefit is generally called synbiotic. Prebiotics is nonviable nutritional food substance used to support the growth of live beneficial microorganism while nonpathogenic live microorganisms that can be taken orally for well-being assistance for human are defined as probiotics. It is evident that the gut microflora composition can be altered through diet. Probiotic bacteria are associated with the manufacturing of healthy nutritional food and can directly be used to manage different disease conditions. Some health-beneficial bacteria such as genera Bifidobacterium and Lactobacillus, Escherichia, Enterococcus, Streptococcus, and Saccharomyces are the most common and available as marketed products. Combinatorial use of pre- and probiotic provides synergistic health beneficial effects, and it supports the growth of beneficial microorganisms that results in improved human health. It was clinically proven that synbiotics can provide a health gain and also provide symptomatic relief in different pathogenic conditions. Synbiotics can synergize the action of a particular drug which are used for a specific disease. Dietary intrusion for gut microbiota is possible, and it has been clinically confirmed in many studies. It is clinically proven it improves the health of patients who suffered from gut or Inflammatory bowel disease (IBD) syndrome. It can provide a beneficial role and manage different types of diseases like irritable bowel syndrome, colorectal cancer, enterocolitis, and ulcerative colitis, breast cancer, liver cirrhosis, liver, and lung cancer. It also plays an important role in improving health in case of lactose intolerance, diarrhea, helps in prevention of immunological reactions, stress, constipation, minimization of cholesterol level in plasma, and has antimicrobial benefits. In this chapter, the detailed clinical trial exploration of synbiotic for the management of different diseases has been included.