History Taking and Management of a Neonate Presenting with Jaundice

Areas to focus on: physiologic jaundice, conjugated hyperbilirubinemia (biliary obstruction such as neonatal cholestasis, biliary atresia), inherited hemolytic anemias (hereditary spherocytosis and elliptocytosis), iso-immune-mediated hemolysis (blood group or rhesus incompatibility), erythrocyte enzymatic defects (glucose-6-phosphate dehydrogenase deficiency, pyruvate kinase deficiency, and congenital erythropoietic porphyria), or impaired bilirubin conjugation (Gilbert syndrome, Crigler Najjar syndrome).