Dendrimers-Mediated Delivery of Phytoconstituents

The potential for dendrimers, highly branching three-dimensional macromolecules, to function as drug delivery vehicles has been extensively investigated. They have special qualities such as a well-defined structure, a large surface area, and the capacity to capture and release many kinds of chemicals, including naturally derived compounds. Phytoconstituents (PCs) are naturally occurring chemical substances that are present in plants and have a range of medicinal benefits. However, problems including poor solubility, low adsorption, and instability frequently constrained their practical utilization. Dendrimers are capable of binding PC molecules either on their surface or within their internal cavities and assist their regulated and targeted delivery in vivo, mainly by advancing their solubility and stability or enabling their controlled release, targeting, and combinational therapy. Thus, as a whole, dendrimers provide promising approaches for the effective delivery of PCs, eliminating their shortcomings and enhancing their therapeutic potential. Still, dendrimer-based delivery systems are a topic of current study and further research is required to understand the physicochemical and biological properties of dendrimers, their interaction with PCs, and strategies of dendrimer-PC formulation development, which may improve the designing, effectiveness, and safety aspects of dendrimer-based PC delivery systems.