Fluorescence Energy Transfer Computing

This chapter presents the concept and implementation of fluorescence energy transfer computing, specifically utilizing Förster resonance energy transfer (FRET) between molecular fluorophores and quantum dots. FRET is a non-radiative form of excitation energy transfer that depends on the configuration and optical properties of molecular fluorophores and quantum dots. By designing energy flows through FRET, signal processing can be implemented to perform desired operations. Because the phenomenon occurs at the nanometer scale, miniaturization of information devices can be expected. This chapter reviews the concepts of FRET computing and the implementation of FRET computing devices. Then, a framework of DNA scaffold logic, which systematically handles FRET-based logic operations, is described. Finally, the idea of a FRET network is discussed as a method for enhancing FRET computing performance.