Gestational Trophoblastic Disease

Gestational trophoblastic disease (GTD) encompasses a range of pregnancy-related disorders categorized by an autonomous overgrowth of fetal chorionic tissue or trophoblast that includes benign, premalignant conditions, complete and partial hydatidiform mole, malignant disorders of invasive mole like choriocarcinoma, epithelial trophoblastic tumor and placental site trophoblastic tumor. Hydatidiform mole is the most common and benign subtype of the disease. The persistent/malignant forms of the disease are called gestational trophoblastic neoplasia (GTN). This chapter describes the management of GTN.