Gastroenteropancreatic Neuroendocrine Tumors

Gastroenteropancreatic neuroendocrine tumors are a heterogeneous group of tumors with increasing incidence and variations in epidemiology as per geographical location. Wide acceptance of the WHO classification and grading system has resulted in uniformity in data reporting and understanding of these tumors. Clinical features are characteristic of the particular organ of the primary site and also depend on whether the tumors are functional (hormone-secreting) or non-functional. Carcinoid syndrome and crisis are uncommon but characteristic manifestations of midgut neuroendocrine tumors. Recent developments in imaging that allow accurate assessment of the extent of disease, advances in surgery, and systemic therapy have resulted in improved clinical outcomes as well as improved quality of life in these patients.