Earthquakes can lead to significant damage in buildings. The extent of this damage is directly proportional to Inter-Storey Drift (ISD). Base Isolation (BI) and Concentric Braced Frames (CBF) are two of the most common systems that are used to limit ISD in buildings. This research is divided into two sections. In Section 2, cost analysis is done for BI and CBF buildings by designing them for MCE (Maximum Considered Earthquakes) and medium soil conditions as per the design guidelines of Indian and American codes. In Section 3, Non-Linear Time History Analysis (NLTHA) is executed to assess the performance of both the building model on their ability to minimize the ISD (post-earthquake importance) for three ground motions corresponding to medium soil condition. Conventional diagonal cross (“X”) braces have been considered in the CBF system. Standard properties of Lead Rubber Bearing (LRB) have been used for isolators. Two steel buildings (one each for BI and CBF) have been modeled in SAP 2000, and then both buildings are compared based on cost and ISD. Finally, concluding remarks are given for the best possible system in Earthquake Resistance Design of structures (EQRD).