There has been a surge in demand for blast resistant architecture for significant buildings like hospitals, government buildings, etc. due to the fear of conflict increasing globally. The pressure created on a structure as a result of an explosion is extremely high and lasts for a very little period of time, meaning the impact on the building is highly severe and can result in significant structural damage. Significant structures need to be built in a way that they can withstand those intense pressures without suffering any major collapse. Blast loads are estimated in accordance with the steps outlined in IS 4991. Pressure intensity from IS 4991 has been calculated and converted to point loads acting at each level as per the distance from the blast source. The response spectrum analysis is also performed for seismic loading along with blast loads and parameters such as maximum lateral displacement, maximum story drift ratio, time period, maximum over-turning moment etc. are compared to assist the performance of the building. Also the blast load intensity has been varied as well as the standoff distance to estimate the effect of blast loads at various standoff distances and intensities. Expected outcomes from this project will be to understand the effect of accidental blast loading at some distance from the building and after analyzing the above cases some remedies for reducing the effects of blast loads by introducing shear walls and composite steel-RCC columns of the building has been suggested. The structural analysis is performed in finite element software i.e. ETABS and SAP2000.