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Nicotinamide adenine dinucleotide phosphate (NADPH), also known as reduced coenzyme II, is pivotal in attenuating neuroinflammation, sustaining the oxidative reduction state, and maintaining mitochondrial function. Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) share common pathological features, including mitochondrial impairment, oxidative stress, and neuroinflammation caused by protein aggregates. This chapter discusses the prospective therapeutic applications of NADPH in addressing AD and PD.

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NADPH and Alzheimer’s Disease and Parkinson’s Disease

  • 章节

  • 发表日期：

    2025年

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  • Da-Chuang Yang,
  • Ying Cheng,
  • Fang Lin

摘要

Nicotinamide adenine dinucleotide phosphate (NADPH), also known as reduced coenzyme II, is pivotal in attenuating neuroinflammation, sustaining the oxidative reduction state, and maintaining mitochondrial function. Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) share common pathological features, including mitochondrial impairment, oxidative stress, and neuroinflammation caused by protein aggregates. This chapter discusses the prospective therapeutic applications of NADPH in addressing AD and PD.