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This chapter first explores the molecular identification of the oxidized form of NAD+ and then elucidates its three main sources, namely, the de novo synthesis pathway, the Preiss–Handler pathway, and the salvage pathway. It also points out that the distribution of NAD+ in cells is uneven. The study of NAD+ biology has been reinvigorated by the growing understanding of the regulatory processes and therapeutic potential of NAD+.

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Identification, Source, and Intracellular Distribution of Nicotinamide Coenzyme I

  • 章节

  • 发表日期：

    2025年

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  • Jinhua Shen,
  • Shuo Li,
  • Na Liu,
  • Qiao Huang,
  • Yi Rui,
  • Yan Wang

摘要

This chapter first explores the molecular identification of the oxidized form of NAD+ and then elucidates its three main sources, namely, the de novo synthesis pathway, the Preiss–Handler pathway, and the salvage pathway. It also points out that the distribution of NAD+ in cells is uneven. The study of NAD+ biology has been reinvigorated by the growing understanding of the regulatory processes and therapeutic potential of NAD+.