Among plant parasitic nematodes (PPNs), Meloidogyne spp. are posing serious losses to agriculturally important crops worldwide. They make complex interactions with the roots of their host plants and hijack the immune machinery of plants. Various intensive practices like the use of chemical nematicides have been practiced to control the attack of these noxious parasites. Indiscriminate application of these chemicals is responsible for the deterioration of the environment and human health. Given environmental concerns, alternative effective strategies are needed to enhance the overall health of plants and to successfully manage the PPNs. Bioconversions such as vermicompost are rich in humus and beneficial microbes and have the potential to reduce the populations of parasitic nematodes in plant rhizosphere. Various factors of vermicompost act synergistically to work against plant pathogens. Vermicompost application improves various physical and biochemical characteristics of the soil that in turn enhances the growth and immunity of plants. Foliar application, soil drenching, or seed soaking in vermicompost tea also proves beneficial for controlling the attack of parasitic nematodes. Toxic substances like hydrogen sulfide, ammonia, and nitrite released by vermicompost and vermicompost teas negatively affect the survival of parasitic nematodes at different developmental stages. Apart from this, their soil application invites various predatory nematodes and nematophagous fungi which selectively reduce the populations of parasitic nematodes. Such eco-friendly organic approaches can be used as alternatives to chemical nematicides and fertilizers without affecting human health and the environment and for the production of chemical-free food in the future.