Mammography, a cornerstone in detection of breast cancer, relies on standardized reporting systems such as the Breast Imaging Reporting and Data System (BI-RADS) to ensure uniform interpretation and communication of findings. Over the last few decades, mammography has undergone significant advancements. Digital mammography has essentially superseded traditional film-screen mammography, resulting in higher image quality, faster processing, and easier image storage and retrieval. Furthermore, the introduction of digital breast tomosynthesis has transformed mammographic screening by producing multiplanar reconstructed images that minimize the influence of overlapping breast tissue and enhance cancer detection rates, particularly in women with dense breasts. This chapter aims to provide an overview of the BI-RADS lexicon and its application in mammography interpretation along with a brief discussion about digital breast tomosynthesis.