The matter of prevention, whether it is infectious diseases or any other cause, has been a major concern worldwide. Yet, it has been proven that nanomaterials possess extraordinary properties and their integration with polymers or other bioactive substances could lead to groundbreaking medical assistance. However, a lack or scarcity of research and clinical data is inadequate to demonstrate clinical trial data and its advantages. Indeed, forced action is required for in-depth studies, more intensive clinical trials and explanations, and collaborations between hospitals, industries, laboratories, or clinicians. The exhaustive testing of nanomaterials is believed to open new doors in preventing infections. Nano-Shields can dramatically improve efficacy and compliance in modern-day vaccination and be of immense benefit to reduce the cost of vaccination manufacturing and transportation. Nano-Shields can serve as low-cost infection prevention measures with extended efficacy for 3–7 days with one-time use, offering an increased degree of personal protection against pathogens with respiratory and ocular routes of transmission. Nano-Shields are also reusable and could benefit healthcare workers, school-going children, and any individual working in overcrowded indoor spaces. Finally, Nano-Shields are beneficial for those with preexisting lung illnesses and could potentially be the new vaccine adjuvant of choice to increase desired immune responses, save time, and ensure resources for new vaccine production.