Dietary bioactive compounds are additional nutritious elements found in small amounts in foods. Different bioactive compounds are essential for bone health. The biomineral framework of bone is composed of approximately 70% inorganic calcium hydroxyapatite (HA) crystals Ca10 (PO4)6(OH)2. The remaining 30% is made up of organic materials. Certain peptides, including ECM-Derived Peptides, BMP-Derived Peptides, and Other Peptides, can promote and accelerate the bone recovery process. Peptide structure alteration may enhance antibacterial, proangiogenic, and immune-modulating activities. Proteins are constructed from amino acids. Polar and charged amino acids (AAs) are ubiquitous in non-collagenous peptides and play a role in the activation of bone. The importance of growth variables in bone regeneration has long been acknowledged. Growth factors are a type of polypeptide hormone that stimulates a variety of biological activities, including cell growth, chemotaxis differentiation, and ECM protein creation. They also control the creation and function of local factors that have an immediate impact on cellular metabolism (autocrine and paracrine actions). Because of their antioxidant and anti-inflammatory effects, phytochemicals, particularly flavonoids, may benefit bone health. It’s possible that phytosterols influence osteoblast growth and differentiation. Oxysterols are tiny, cholesterol-derived compounds found in both human and animal tissues and blood flow which have been shown to be osteo inductive. Liposomes are biocompatible lipid-based vesicles that are commonly employed in bone repair therapy. Statins are popular drugs that are used to decrease LDL cholesterol levels to avoid atherosclerosis. Bacterial cellulose is an exciting biopolymer which can be employed in the creation of modern biomaterials for the directed rebuilding of bone tissue due to its biocompatibility, biodegradability, high crystallinity, porosity, and tensile strength with mechanical resilience.