Food provides a variety of nutrients that are vital to human health, as well as chemical components present in food with bioactive attributes believed to be crucial for both preventing illness and health promotion. Food bioactive compounds have garnered attention recently due to its significant therapeutic values, and there is discussion on how to utilize these, when making recommendations for public health as nutraceuticals. Food bioactives are naturally occurring biologically active chemical components derived from various food sources (plants, animal and microbial), which possess significant therapeutic properties against various ailments. Food or food products contains an abundant amount of bioactive compounds such as (alkaloids, glycosides, phenol, tannins, carotenoids), which is considered for its therapeutic efficacy against various clinical disorders such as cardiovascular issues, diabetes, inflammatory disease, cancer, arthritis and immune-modulators. Therefore, food or food bioactive can play a very significant role as nutraceuticals for the management of various therapeutic illness. A nutraceutical is a “food or food bioactive obtained from plant or animal with significant health benefits” mostly employed to prevent or cure diseases. In this chapter, efforts were made to bring altogether the possible wide range of various food bioactive compounds present in food and its possible application as nutraceuticals. Additionally, this chapter will also draw the interest of nutritionists, food scientists, pharmaceutical industries and food businesses in order to improve the application of bioactive molecules in nutraceutical industry and facilitate their commercialization in order to support and promote wellness, wellbeing, and a healthy lifestyle.