This paper studies the site selection problem for aviation emergency logistics centers. Based on the different task requirements faced by aviation emergency logistics centers, they are divided into two categories: first level aviation emergency logistics centers and secondary aviation emergency logistics centers. For first level aviation emergency logistics centers, a comprehensive evaluation model using the TOPSIS method based on entropy weight is applied for site selection. For secondary aviation emergency logistics centers, a multi-objective model aimed at minimizing costs and maximizing coverage area is established, and the NSGA-II algorithm is used for site selection and solution. Finally, using the Northwest region of China as a case study background, the feasibility and practicality of the models are discussed. The optimal site selection schemes for aviation emergency logistics centers when the number is 10, 13, and 15 are calculated, and the universality and feasibility of the two models proposed in this paper are analyzed.