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The field of pharmaceutical sciences has witnessed remarkable progress in recent years, particularly in the formulation of drug nanocrystals. Nanocrystals represent a promising approach to address challenges associated with the solubility and bioavailability of poorly water-soluble drugs. Nanocrystals are microscopic particles with dimensions typically in the nanometre range, from 1 to 100 nm in size. They are a type of nanomaterial characterized by their small size and large surface area relative to their volume. Nanocrystals can be composed of various materials, including metals, semiconductors, or organic compounds. Their enhanced surface area, a consequence of being in the nanometre range, contributes to improved reactivity and dissolution rates. This chapter comprehensively covers the fundamental principles and innovative techniques employed in the production of drug nanocrystals, emphasizing methodologies such as high-pressure homogenization, wet milling, and precipitation methods. It has also given considerable information about the selection and design of stabilizers and surfactants, crucial for ensuring the stability and performance of nanocrystals. It explores the implications of nanocrystal technology on drug delivery systems, elucidating how the enhanced surface area and dissolution rates of nanocrystals contribute to improved bioavailability. This discussion extends to the incorporation of nanocrystals into various dosage forms, including oral tablets, injectables, and topical formulations, highlighting their versatility and potential for personalized medicine. In the commercial landscape, various pharmaceutical companies have utilized the potential of nanocrystals in drug formulations. Products such as TRIGLIDE, EMEND, and MEGACE ES incorporating nanocrystals have been developed to improve the delivery and performance of drugs with low solubility, addressing a critical need in the industry. These commercial products underscore the successful translation of nanocrystal research into practical solutions, marking a significant stride forward in the field of pharmaceutical sciences.

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Advances and Developments in Formulation of Drug Nanocrystals

  • 章节

  • 发表日期：

    2025年

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  • Manshi,
  • Sonal Setya,
  • Sushama Talegaonkar

摘要

The field of pharmaceutical sciences has witnessed remarkable progress in recent years, particularly in the formulation of drug nanocrystals. Nanocrystals represent a promising approach to address challenges associated with the solubility and bioavailability of poorly water-soluble drugs. Nanocrystals are microscopic particles with dimensions typically in the nanometre range, from 1 to 100 nm in size. They are a type of nanomaterial characterized by their small size and large surface area relative to their volume. Nanocrystals can be composed of various materials, including metals, semiconductors, or organic compounds. Their enhanced surface area, a consequence of being in the nanometre range, contributes to improved reactivity and dissolution rates. This chapter comprehensively covers the fundamental principles and innovative techniques employed in the production of drug nanocrystals, emphasizing methodologies such as high-pressure homogenization, wet milling, and precipitation methods. It has also given considerable information about the selection and design of stabilizers and surfactants, crucial for ensuring the stability and performance of nanocrystals. It explores the implications of nanocrystal technology on drug delivery systems, elucidating how the enhanced surface area and dissolution rates of nanocrystals contribute to improved bioavailability. This discussion extends to the incorporation of nanocrystals into various dosage forms, including oral tablets, injectables, and topical formulations, highlighting their versatility and potential for personalized medicine. In the commercial landscape, various pharmaceutical companies have utilized the potential of nanocrystals in drug formulations. Products such as TRIGLIDE, EMEND, and MEGACE ES incorporating nanocrystals have been developed to improve the delivery and performance of drugs with low solubility, addressing a critical need in the industry. These commercial products underscore the successful translation of nanocrystal research into practical solutions, marking a significant stride forward in the field of pharmaceutical sciences.