Recent advancement in ophthalmic drug delivery is mostly concentrated on medication administering in the form of simple eye drops. Novel, innovative ophthalmic dosage forms possess advancement such as sustained release, less dosing frequency and improved ocular bioavailability and permeability. The present chapter will give an overview of the recent progress and challenges related to advanced ophthalmic dosage forms in addition to anatomy of the human eye and barriers which will be under consideration while developing ophthalmic drug delivery systems. Application of 3DP (three-dimensional printing) in advancement of ocular delivery systems will also be discussed in detail along with the evaluation tests and their regulatory considerations.