The Yamuna River is a prominent watercourse in northern India that intersects with the nation's capital, New Delhi, where urban development shapes its morphological trajectory. This study employs GIS techniques and remote sensing data to study two decades (2001–2021) of morphological changes along a 150-km stretch of the Yamuna River near New Delhi by dividing it into six reaches. This study explores centerline shifts, river width alterations, and sinuosity variations of the water channel of the river, to understand the morphological parameters of the river. The findings reveal a trend of decreasing centerline deviation in 2011 compared to 2001, indicating increasing stability in the river channel over time, unraveling the dynamic interplay of natural forces and human interventions. Sinuosity Index (SI) values predominantly categorize the river as sinuous, with the last reach classified as meandering. The third and fourth reaches, characterized by constant SI values and minimal centerline shifts, signify stable river morphology attributed to urban infrastructure influence. This research provides crucial insights into the dynamic behavior of the Yamuna River, essential for informed environmental management and sustainable urban development strategies.