Certainly, the allure of handmade fashion textiles unquestionably emanates from the human touch they embody. Time-honored techniques showcase a mastery of skills, resulting in creations imbued with vitality and rich history. Despite a long-standing demand for handmade products, the contemporary market poses formidable challenges for local artisans in the face of globalization. Adapting to the needs of vast international clientele without the backing of large-scale production infrastructure presents a considerable hurdle. In the modern business landscape, the infusion of technology is already revitalizing traditional crafts, ushering in new opportunities. The primary objective of this study is to investigate the impact of 3D technology on transforming the dynamics of handmade fashion, shifting from baby boomers to millennials. Examining the craft of Kalamkari in Machilipatnam, Andhra Pradesh, India, through field research unveiled the intricate process of woodblock creation involving various mechanical devices and tools. The continuous depletion of trees and reliance on the heartwood of perennial trees may not align with contemporary sustainability goals. In response to these challenges, 3D printing technology, an additive manufacturing process utilizing digital designs, has emerged. Rapid and supported by cutting-edge software and materials, 3D printing facilitates the quick and detailed production of scaled models. Consequently, the study aims to compare the outcomes of block printing using wooden blocks crafted by hand and blocks created through 3D printing with PLA, a polymer filament. Utilizing desktop modeling software and the ENDER™ 3D printing machine, PLA blocks were produced in the same pattern. The study assesses block performance by comparing fabrics printed with pigments, reactive dyes, and natural indigo on cotton fabric. The evaluation of visual, technical, and ergonomic aspects of block printing indicates that 3D-printed PLA blocks hold significant potential for incorporation into block printing techniques.