Quantum dots are zero-dimensional semiconductor nanoparticles with ultrafine sizes in a range of 2–10 nm. Such small sizes give quantum dots (QDs) unique optical, physical, and chemical properties. QDs are made of heavy metals in the core and covered with a shell. Due to an increase in concerns about the cytotoxicity of QDs, there has been an increased focus on the synthesis of more biocompatible QDs, such as carbon quantum dots (CQDs). Carbon quantum dots (CQDs) are carbon-based fluorescent nanoparticles. CQDs mainly consist of carbon; therefore, the synthesis procedure requires carbon sources that are non-toxic and abundant in nature. Furthermore, chemical stability, biocompatibility, low toxicity, ecological safety, high solubility, excellent photoluminescence, and optical characteristics are some of the remarkable properties of CQDs. These features make CQDs excellent tools for various research fields including bioimaging, biosensors, drug delivery systems, solar cells, and food packaging. Recently, CQDs have been used as nanofillers, photoluminescent, antimicrobial, antioxidant, and UV-light-blocking agents in food packaging materials. This chapter overviews the synthesis methods along with functionalization and CQDs applications for food preservation. Moreover, its potential for the development of active and intelligent food packaging and contributions to film properties are presented.