Myasthenia Gravis

Myasthenia gravis is the most common immunological disease of the neuromuscular junction. It affects young females and elderly males and is associated with other immunological disorders. A proportion of patients have thymoma. External ocular muscles, eyelids, muscles of mastication, and swallowing are preferentially affected by the disease. A myasthenic crisis forms a medical emergency and urgent intensive therapy is required. The course is fluctuating, and remissions and exacerbations are known. The type of antibody has some bearing on the presentation, course, and therapy options. Long-term immunosuppression and medical monitoring are required for most patients. Advances in intensive care, judicious use between available options in immunosuppression, and newer targeted therapies have improved the quality of life.