Distal Hereditary Motor Neuropathy (dHMN)

Distal hereditary motor neuropathies (dHMN) result in chronic progressive distal weakness. The sensory system is unaffected clinically and electrophysiologically. These conditions are transmitted as autosomal dominant, recessive, and X-linked, and a wide array of genetic defects has accumulated in each category. Key clinical features help the differentiation of subtypes but the overlap with Charcot-Marie tooth disease and familial amyotrophic lateral sclerosis exists.