Limb-Girdle Muscular Dystrophies

Limb-girdle muscular dystrophies (LGMDs) are a large group of autosomal muscular dystrophies, transmitted as dominant (LGMD D) and recessive (LGMD R). Presently, at least 30 different genetic subtypes of LGMDs have been described. All share the broad denominator of limb-girdle weakness; some specific clinical features are known to broadly correlate with the molecular diagnosis. Presently, no definitive therapy exists, and prevention and supportive therapy can be useful.