The study is presented for transient bed profile computation for cohesive mixture of clay-silt-gravel. The transient bed profiles were measured at the middle of flume width at a longitudinal interval of 50 cm along the flow direction for different percentage of clay in the sediment mixtures of clay-silt-sand. Transient bed profile, i.e., degradation of bed varied with the clay percentage in the sediment mixture as well as with the excess shear stress. The variation of bed degradation with the clay percentage indicates that degradation of channel bed decreases with the increase of clay percentage. The variation of bed degradation with excess shear stress developed by the incoming flow indicates that the channel bed degradation increases with the increase of excess shear stress. The variation of bed degradation with time shows that the variation in bed degradation decreases with the increase of time interval, i.e., higher variation observed in the initial interval of time and after that it decreases. It found that the maximum degradation occurred at 50 cm longitudinally from the entrance of upstream working section for the present cohesive sediment mixture. The relationship proposed for the computation of transient bed profile for the cohesive sediment mixture in the present study based on the functional relationship expressed in terms of dimensionless clay content, excessive shear stress, and time. The computed and observed transient bed profile found to be satisfactory and close to each other.